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Polyether antibiotic CP44,161.

P Allen1, M A Brimble, P Turner

  • 1School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia.

Acta Crystallographica. Section C, Crystal Structure Communications
|February 15, 2001
PubMed
Summary
This summary is machine-generated.

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The crystal structure of antibiotic CP44,161 was determined using X-ray crystallography. This complex molecule forms a stable cyclic conformation, aided by hydrogen bonding from a central water molecule.

Area of Science:

  • Chemical crystallography
  • Structural biology
  • Natural product chemistry

Background:

  • Antibiotic CP44,161 is a complex natural product with a unique chemical structure.
  • Understanding the three-dimensional structure of antibiotics is crucial for drug development and mechanism of action studies.

Purpose of the Study:

  • To elucidate the precise crystal structure of antibiotic CP44,161 monohydrate.
  • To investigate the molecular conformation and intermolecular interactions of the antibiotic.

Main Methods:

  • X-ray crystallography was employed to determine the crystal structure.
  • Single crystal X-ray diffraction data was collected and analyzed.

Main Results:

  • The crystal structure of antibiotic CP44,161 monohydrate (C43H66O10.H2O) was successfully determined.

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  • The molecule adopts a stable cyclic conformation.
  • A central water molecule forms hydrogen bonds, stabilizing the overall structure.

    • Conclusions:

    • The determined crystal structure provides detailed insights into the molecular architecture of antibiotic CP44,161.
    • The conformational stability is influenced by intramolecular and intermolecular hydrogen bonding, particularly involving the water molecule.