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nm23-H1 Expression in Squamous Cell Carcinoma of the Head and Neck
John S McDonald1, Peter S Gartside, Ljiljana J Pavelic
1University of Cincinnati College of Medicine, Department of Otolaryngology-Head and Neck Surgery, Cincinnati, USA.
Abstract:
Archival material from 47 patients with primary squamous cell carcinoma of the head and neck (SCCHN) was studied immunohistochemically for the presence of nm23-H1 protein. Our data indicate that nm23-H1 protein expression is a common event in SCCHN and that there is a trend toward correlation of increased expression of nm23-H1 with increasing tumor size (p = 0.072). The results also show that when adjusting for age and cause of death, there tended to be an inverse relationship between overall survival and the expression of nm23-H1 gene in the primary tumor (p = 0.088).
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