Death by design: the big debut of small molecules

TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade.

Annals of the rheumatic diseases·2009

Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary.

Endocrinology·2001

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3.

Development (Cambridge, England)·2000

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.

Nature medicine·2000

Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.

Journal of neuropathology and experimental neurology·2000

Circadian control of circulating tumour-derived extracellular vesicle secretion affects targeted therapy efficacy.

Nature cell biology·2026

DREAMS illuminates spatial DNA and RNA modification landscapes.

Nature cell biology·2026

A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability.

Nature cell biology·2026

Mechanisms underlying propagation of ferroptotic cell death.

Nature cell biology·2026

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

Nature cell biology·2026

Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia.

Nature cell biology·2026

Molecules to market: A probabilistic artificial intelligence framework for predicting managed care adoption at the level of drug discovery.

Journal of managed care & specialty pharmacy·2026

Curcumin Bound Seleno-BSA, a Novel Bifunctional Macromolecular Therapeutic System Against A549 Lung Cancer Cells: Photophysical Characterizations, Cellular Uptake, and Efficacy.

Chemistry, an Asian journal·2026

Investigating angiotensin II concentration in modulating Plasmodium falciparum infection and angiotensin receptor activation.

Frontiers in parasitology·2026

Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation.

ChemMedChem·2026

AI-powered medicinal chemistry and translational drug development.

Chemical Society reviews·2026

Beyond the flat screen: evaluating virtual reality as a complementary tool for molecular docking in drug discovery.

Journal of computer-aided molecular design·2026

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Death by design: the big debut of small molecules

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TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade.

Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary.

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3.

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.

Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.

Circadian control of circulating tumour-derived extracellular vesicle secretion affects targeted therapy efficacy.

DREAMS illuminates spatial DNA and RNA modification landscapes.

A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability.

Mechanisms underlying propagation of ferroptotic cell death.

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia.

Molecules to market: A probabilistic artificial intelligence framework for predicting managed care adoption at the level of drug discovery.

Curcumin Bound Seleno-BSA, a Novel Bifunctional Macromolecular Therapeutic System Against A549 Lung Cancer Cells: Photophysical Characterizations, Cellular Uptake, and Efficacy.

Investigating angiotensin II concentration in modulating Plasmodium falciparum infection and angiotensin receptor activation.

Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation.

AI-powered medicinal chemistry and translational drug development.

Beyond the flat screen: evaluating virtual reality as a complementary tool for molecular docking in drug discovery.

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Death by design: the big debut of small molecules

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