Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemokines and disease.

C Gerard1, B J Rollins

  • 1Department of Pediatrics, Perlmutter Laboratory, Children's Hospital, Boston, MA, USA. gerard_c@gonzo.tch.harvard.edu

Nature Immunology
|March 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut commensal Bacteroides faecichinchillae, a potential novel candidate of next-generation probiotics targeting type 2 diabetes.

Beneficial microbes·2026
Same author

Ultrasound- and clinical-defined disease activities are associated with altered bone microarchitecture and lower bone mineral density in patients with rheumatoid arthritis.

Aging clinical and experimental research·2025
Same author

Predicted essential fatty acid intakes for a group of dairy cows also apply at individual animal level.

Animal : an international journal of animal bioscience·2023
Same author

Immuno-oncology approaches in uveal melanoma: tebentafusp and beyond.

Immuno-oncology technology·2023
Same author

Quantitative relationships between ingested and intestinal flows of linoleic and alpha-linolenic acids, body weight and milk performance in mid-lactation dairy cows.

Animal : an international journal of animal bioscience·2022
Same author

Rapid tests and transfusion safety in Niamey, Niger.

Medecine et sante tropicales·2017
Same journal

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.

Nature immunology·2026
Same journal

Mechanosensing by T cells promotes a tissue-resident memory transcriptional program.

Nature immunology·2026
Same journal

Editorial Expression of Concern: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

Nature immunology·2026
Same journal

Inflammatory immune modulators of AML lung infiltration and respiratory failure.

Nature immunology·2026
Same journal

The neuroimmune system and cognition.

Nature immunology·2026
Same journal

Critical connections.

Nature immunology·2026
See all related articles

This study reviews diseases linked to improper chemokine network activation, including cardiovascular, inflammatory, and HIV-associated conditions. It highlights potential new therapeutic strategies targeting this critical biological system.

Area of Science:

  • Immunology
  • Pathophysiology
  • Pharmacology

Background:

  • Chemokines are crucial for immune cell trafficking.
  • Inappropriate chemokine network activation is implicated in various diseases.
  • Understanding these pathways is vital for therapeutic development.

Purpose of the Study:

  • To review diseases associated with aberrant chemokine network signaling.
  • To discuss current and future therapeutic strategies targeting chemokines.
  • To consolidate evidence from clinical and animal studies.

Main Methods:

  • Literature review of pathological states linked to chemokine dysregulation.
  • Analysis of clinical observations and animal models.
  • Synthesis of data on cardiovascular disease, allergic inflammation, transplantation, neuroinflammation, cancer, and HIV-associated disease.

Related Experiment Videos

Main Results:

  • Compelling data link chemokine network dysregulation to significant diseases.
  • Specific examples include cardiovascular disease, allergic inflammation, and neuroinflammation.
  • Cancer and HIV-associated diseases also demonstrate chemokine involvement.

Conclusions:

  • Targeting the chemokine network offers promising therapeutic avenues.
  • The field is rapidly evolving with potential for novel treatments.
  • Further research is warranted to fully exploit chemokine-based therapies.