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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
Published on: March 19, 2016
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Research opportunities in transfusion medicine
1Joint Program in Transfusion Medicine at Children's Hospital, Dana Farber Cancer Institute, and Brigham and Women's Hospital, Bader 4, 300 Longwood Ave, Boston, MA 02115, USA.
JAMA
|February 15, 2001
Summary
Transfusion medicine advances now include novel cellular therapies and better understanding of immune responses. This evolution ensures safer blood supply and enables new treatments for cancer and organ regeneration.
Area of Science:
- Transfusion Medicine
- Cellular Therapy
- Immunology
Background:
- Basic research in transfusion medicine has spurred the development of novel cellular therapies.
- Well-characterized cell populations from bone marrow or blood are key to these therapies.
Purpose of the Study:
- To highlight advancements in transfusion medicine beyond traditional blood banking.
- To discuss the potential of refined cell therapies in various medical applications.
- To emphasize the improved understanding and management of immune consequences in transfusion therapy.
Main Methods:
- Isolation of well-characterized cell populations (e.g., hematopoietic stem and progenitor cells, T lymphocytes, dendritic cells).
- Application of refined cell therapies for various medical needs.
- Investigation of immune consequences associated with transfusion therapy.
Main Results:
- Cellular therapies show promise for optimal stem cell engraftment, gene therapy, and immunotherapy.
- Opportunities exist to prevent adverse immune responses like platelet refractoriness and graft-vs-host disease.
- Transfusion medicine is recognized as a broad, multidisciplinary field.
Conclusions:
- Transfusion medicine has evolved significantly, encompassing cellular therapies and immune modulation.
- Future advances will enhance current safety measures (donor screening, viral inactivation) for a secure blood supply.
- Cellular therapies hold potential for regenerative medicine and treating complex diseases.
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