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09:29
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Toward mechanism-based cancer care
1Division of Neoplastic Disease Mechanisms, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA. david_livingston@dfci.harvard.edu
JAMA
|February 15, 2001
Summary
Molecular mechanisms of tumor cell behavior have been uncovered over 25 years, transforming cancer diagnosis, prognosis, and treatment. Future cancer care and prevention will be dominated by these molecular insights and new technologies.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Significant progress in understanding tumor cell molecular mechanisms over the past 25 years.
- Established knowledge has already influenced current cancer diagnosis, prognosis, and treatment strategies.
Purpose of the Study:
- To highlight the impact of elucidated molecular mechanisms on cancer care.
- To project the future dominance of molecularly-based approaches in oncology.
Main Methods:
- Review of 25 years of cancer research findings.
- Analysis of the translation of basic science discoveries to clinical practice.
Main Results:
- Detailed understanding of molecular mechanisms has led to improved diagnostic, prognostic, and therapeutic methods.
- Emerging technologies are facilitating the application of basic science in clinical settings.
Conclusions:
- Molecular mechanisms are fundamental to understanding and combating cancer.
- Future cancer care and prevention will be increasingly driven by molecular insights and technological advancements.
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