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Breeding nude (nu/nu) mice.

C M Hetherington, M A Hegan

Laboratory Animals

|January 1, 1975

Summary

This summary is machine-generated.

Using specific breeding methods, researchers found that 50% of offspring were nude mice (nu/nu). While most nude female mice are fertile, only 20% successfully raise their litters to weaning age.

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Area of Science:

Immunology
Genetics
Developmental Biology

Background:

The nude mouse mutation (nu/nu) is characterized by athymia and T-cell deficiency.
Conventional breeding strategies are employed to generate and study nude mice.

Purpose of the Study:

To investigate the reproductive success of nude mice (nu/nu) under conventional conditions.
To determine the litter-rearing capabilities of fertile nude female mice.

Main Methods:

Utilizing homozygous nude males with thymus grafts from normal siblings as sires.
Cross-breeding these males with heterozygous females.
Monitoring offspring for the nude phenotype (nu/nu).
Assessing the fertility and litter-rearing success of nude females.

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Main Results:

Heterozygous females yielded 50% nu/nu offspring when bred with the specified sires.
A majority of the resulting nu/nu females were found to be fertile.
Only 20% of these fertile nu/nu females successfully reared their litters to weaning age.

Conclusions:

The study confirms a 50% yield of nu/nu offspring through specific breeding.
Nude female mice exhibit reduced litter-rearing success despite fertility.
This highlights a significant challenge in maintaining nude mouse colonies.