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Validation of an outcomes instrument for tonsil and adenoid disease
M G Stewart1, E M Friedman, M Sulek
1Bobby R Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, TX 77030, USA. mgstew@bcm.tmc.edu
Insights
A new health status instrument was developed for children with tonsil and adenoid disease. The Tonsil and Adenoid Health Status Instrument is reliable, valid, and sensitive for research.
Area of Science:
- Pediatric Otolaryngology
- Health Outcomes Research
- Psychometrics
Background:
- Tonsil and adenoid diseases are common in children, impacting their health status.
- Existing instruments may not adequately capture disease-specific health status in this population.
Purpose of the Study:
- To design and validate a disease-specific health status instrument for children with tonsil and adenoid disease.
- The instrument, named the Tonsil and Adenoid Health Status Instrument, aims to improve outcomes research.
Main Methods:
- Prospective psychometric and clinimetric validation in three stages.
- Included item testing, reliability and validity testing (test-retest, internal consistency, content, construct, criterion), factor analysis, and responsiveness analysis.
- Conducted in pediatric specialty hospitals with 224 children diagnosed with tonsil and adenoid disease.
Main Results:
- Factor analysis confirmed 6 distinct subscales: eating/swallowing, airway/breathing, infections, healthcare utilization, cost of care, and behavior.
- The Tonsil and Adenoid Health Status Instrument demonstrated excellent test-retest reliability (r=0.72-0.88) and internal consistency (Cronbach's alpha=0.73-0.87).
- Content, construct, and criterion validity were satisfactory, and the instrument showed appropriate sensitivity to change.
Conclusions:
- The Tonsil and Adenoid Health Status Instrument is a valid, reliable, and sensitive tool.
- It possesses significant utility for outcomes research in pediatric tonsil and adenoid disease.
Objective:
To design and validate a disease-specific health status instrument-the Tonsil and Adenoid Health Status Instrument-for use in children with tonsil and adenoid disease.
Design:
Prospective psychometric and clinimetric instrument validation in 3 stages.
Settings:
A tertiary academic pediatric specialty hospital and a tertiary academic hospital, in 2 different cities. PATIENTS/OTHER PARTICIPANTS: Children with tonsil and adenoid disease presenting for evaluation and treatment (n = 224). INTERVENTION/METHOD: Prospective instrument validation. Stage 1 consisted of initial item testing, reduction, and subscale construction; stage 2, reliability and validity testing, factor analysis, and final item reduction; and stage 3, responsiveness analysis.
Main Outcome Measures:
Test-retest and internal consistency reliability; content, construct, and criterion validity; orthogonal principal components factor analysis; and response sensitivity analysis.
Results:
Factor analysis and item analysis confirmed 6 distinct subscales measuring different constructs (aspects) of disease-specific health status that are affected by tonsil and adenoid disease: eating and swallowing, airway and breathing, infections, health care utilization, cost of care, and behavior. For each subscale, the Tonsil and Adenoid Health Status Instrument demonstrated excellent test-retest reliability (r = 0.72-0.88) and internal consistency reliability (Cronbach alpha = .73-.87). Content validity was ensured during the design process. Construct validity was demonstrated by means of convergent and divergent validity with a global quality-of-life instrument (the Child Health Questionnaire, version PF28). Criterion validity was also satisfactory. Finally, the instrument was appropriately sensitive, with high standardized response means and effect sizes.
Conclusions:
The Tonsil and Adenoid Health Status Instrument is a valid, reliable, and sensitive instrument with 6 distinct subscales. This instrument has significant utility for outcomes research in children with tonsil and adenoid disease.
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