Changes in pancreahepatoduodenal organs during experimental acute lipogenic pancreatitis
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Updated: Oct 9, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
A D Dibirov1, V A Petukhov, M D Donskova
1Department of Faculty Surgery, Russian State Medical University, Moscow.
Abstract:
Experiments on animals with experimental lipogenic pancreatitis showed that disturbances in lipid metabolism stimulate destructive processes in the pancreas, liver, and spleen. Acute experimental lipogenic pancreatitis is characterized by extensive destructive changes in the pancreatic parenchyma accompanied with fatty necrobiosis of hepatocytes, fatty transformation of the gallbladder wall, and pronounced reaction of the reticuloendothelial stroma in the spleen.
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