Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrogen bonds in polymer folding.

J Borg1, M H Jensen, K Sneppen

  • 1Niels Bohr Institute and Nordita, Blegdamsvej 17, DK-2100, Denmark.

Physical Review Letters
|February 15, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Replicators in Game-of-Life-like automata.

Physical review. E·2025
Same author

Predicting the Binding of Small Molecules to Proteins through Invariant Representation of the Molecular Structure.

Journal of chemical information and modeling·2024
Same author

Observation of the ϒ(3S) Meson and Suppression of ϒ States in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Structure of the space of folding protein sequences defined by large language models.

Physical biology·2024
Same author

Probing Small Bjorken-x Nuclear Gluonic Structure via Coherent J/ψ Photoproduction in Ultraperipheral Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Measurement of the top quark mass using a profile likelihood approach with the lepton + jets final states in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023

Hydrogen bonds dramatically reduce entropy in homopolymeric chains, promoting ordered secondary structures. This leads to a helix-to-sheet transition impacting protein folding and prion diseases.

Area of Science:

  • Thermodynamics
  • Polymer Physics
  • Biophysics

Background:

  • Homopolymeric chains exhibit complex thermodynamic behavior influenced by various interactions.
  • Understanding polymer conformations is crucial for molecular biology and disease research.

Purpose of the Study:

  • To investigate the thermodynamic impact of van der Waals and hydrogen bonding on homopolymeric chains.
  • To explore the emergence of secondary structures and conformational transitions.

Main Methods:

  • Thermodynamic analysis of homopolymeric chains.
  • Modeling of van der Waals and hydrogen bond interactions.
  • Investigation of polymer conformational states.

Main Results:

Related Experiment Videos

  • Hydrogen bonds significantly decrease entropy in low-lying states.
  • Observed emergence of long-range order and secondary structures.
  • Identified a transition between helix-rich and sheet-dominated states in compact polymers.

    • Conclusions:

    • The study elucidates the role of hydrogen bonds in polymer structure formation.
    • Findings offer insights into protein folding mechanisms.
    • The conformational transition may have implications for understanding prion diseases.