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Related Experiment Videos

Interkingdom gene fusions.

Y I Wolf1, A S Kondrashov, E V Koonin

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rockville Pike, Bethesda, MD 20894, USA.

Genome Biology
|February 24, 2001
PubMed
Summary
This summary is machine-generated.

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Interkingdom gene fusions (IKFs) combine genetic material from different life kingdoms. These rare events, involving gene transfer and recombination, shape genome evolution, particularly in bacteria like Mycobacterium tuberculosis.

Area of Science:

  • Evolutionary biology
  • Genomics
  • Molecular biology

Background:

  • Lateral gene transfer is a significant force in evolution across Bacteria, Archaea, and Eukarya.
  • Protein domains exhibit mobility, leading to diverse multidomain architectures.
  • Investigated the potential for invading genes to merge with existing genes, creating novel structures.

Purpose of the Study:

  • To identify and analyze interkingdom gene fusions (IKFs) across diverse genomes.
  • To understand the evolutionary mechanisms behind IKF formation.
  • To explore the prevalence and patterns of IKFs in different life kingdoms.

Main Methods:

  • Comparative genomics analysis of complete genomes from bacteria, archaea, and eukaryotes.
  • Phylogenetic analysis to support identified IKFs.

Related Experiment Videos

  • Examination of gene fusion structures and presence of standalone alien domains.

    • Main Results:

    • Identified 37 cases of interkingdom gene fusions (IKFs), where proteins contain domains from different kingdoms.
    • Phylogenetic analysis confirmed 37 IKFs, each with a native and a horizontally acquired 'alien' domain.
    • Mycobacterium tuberculosis exhibited the highest number of IKFs, often with accompanying standalone alien domains.

    Conclusions:

    • Interkingdom gene fusion (IKF) formation is a validated, albeit infrequent, evolutionary process.
    • IKFs likely arise from a two-stage mechanism: lateral gene transfer followed by recombination.
    • Stand-alone intermediate genes are often eliminated, except in Actinomycetes where IKF generation appears active.