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The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation
E Chevet1, P H Cameron, M F Pelletier
1Anatomy and Cell Biology, McGill University, Montreal, Quebec, H3A 2B2, Canada.
Current Opinion in Structural Biology
|February 17, 2001
Abstract:
The endoplasmic reticulum is the entry point into the secretory pathway. To acquire a correct conformation, secretory proteins encounter the endoplasmic reticulum molecular machines of folding, quality control, signaling and disposal, which function as an integrated mechanism. The creation of such a molecular network, spatially regulated, suggests how the endoplasmic reticulum promotes the release of correctly folded secretory proteins.