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Updated: Aug 14, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
Systemic Weber-Christian disease
1Medical University of South Carolina, Department of Dermatology, Charleston, South Carolina, USA.
Background:
Weber-Christian disease is a controversial entity that histologically presents as a lobular panniculitis. A systemic variant of this disorder, in which visceral fat is affected, has been reported.
Objective:
A 29-year-old woman with Weber-Christian disease developed a rapidly enlarging abdominal mass during hospitalization for a flare of her skin condition. The mass resolved spontaneously. Radiographic studies demonstrated a mesenteric cyst, which was thought to represent involvement of mesenteric fat by Weber-Christian disease.
Conclusion:
The appearance of an abdominal or pelvic mass in a patient with Weber-Christian disease may be due to visceral involvement by the inflammatory process.
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