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Related Experiment Videos

Nuclear envelope permeability.

P L Paine, L C Moore, S B Horowitz

    Nature
    |March 13, 1975
    PubMed
    Summary
    This summary is machine-generated.

    The amphibian oocyte nuclear envelope acts as a molecular sieve, controlling what enters the nucleus. Its pores have a specific radius, limiting the passage of molecules like dextrans.

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    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Developmental Biology

    Background:

    • The nuclear envelope regulates transport between the cytoplasm and nucleus.
    • Understanding nuclear pore complex function is crucial for cell biology.

    Purpose of the Study:

    • To determine the permeability of the amphibian oocyte nuclear envelope in situ.
    • To characterize the size-selective properties of the nuclear envelope.

    Main Methods:

    • In situ analysis of amphibian oocyte nuclear envelope.
    • Permeability studies using three tritiated dextrans of varying molecular sizes.

    Main Results:

    • The nuclear envelope functions as a molecular sieve.
    • Molecular movement between the cytoplasm and nucleus is restricted.

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  • The effective pore radius of the nuclear envelope was determined to be approximately 45 angstroms.

    • Conclusions:

    • The amphibian oocyte nuclear envelope exhibits size-dependent permeability.
    • The pore structure limits the passage of molecules larger than a specific radius.
    • These findings contribute to the understanding of nuclear transport mechanisms.