Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Compatible transfusion therapy for paroxysmal cold hemoglobinuria.

A R Rausen, R LeVine, T C Hsu

    Pediatrics
    |February 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Collaborative health systems ECHO: The use of a tele-education platform to facilitate communication and collaboration with recipients of state targeted response funds in Pennsylvania.

    Substance abuse·2022
    Same author

    Effects of beta-1,3-glucan (AletaTM) on vaccination response in broiler chickens.

    Poultry science·2018
    Same author

    Evaluation of the effects of feeding dried algae containing beta-1,3-glucan on broilers challenged with Eimeria.

    Poultry science·2018
    Same author

    Retrospective Evaluation of Horses Diagnosed with Neuroborreliosis on Postmortem Examination: 16 Cases (2004-2015).

    Journal of veterinary internal medicine·2016
    Same author

    Acquired factor V inhibitor after exposure to topical human thrombin related to an otorhinolaryngological procedure.

    Journal of thrombosis and haemostasis : JTH·2015
    Same author

    Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation.

    Biochimica et biophysica acta·2013
    Same journal

    Measles-Associated Stridor.

    Pediatrics·2026
    Same journal

    MTHFR, Pneumonia, and Thrombosis in Children: A Gene-Infection Interaction.

    Pediatrics·2026
    Same journal

    Early Adulthood Outcomes Among Individuals With Neurologic Impairment and Technology Assistance.

    Pediatrics·2026
    Same journal

    Video vs Telephone Consultations for Pediatric Quality of Care in Emergency Departments.

    Pediatrics·2026
    Same journal

    A Resource to Understand and Prevent Sudden Unexpected Infant Deaths.

    Pediatrics·2026
    Same journal

    Influenza Vaccine Effectiveness Against Pediatric Death in the United States: 2016-2025.

    Pediatrics·2026
    See all related articles

    Successful treatment for paroxysmal cold hemoglobinuria (PCH) was achieved in two children using compatible frozen-thawed red blood cells. This transfusion therapy effectively managed the acute hemolytic phase of the syndrome.

    Area of Science:

    • Pediatric Hematology
    • Immunology
    • Transfusion Medicine

    Background:

    • Paroxysmal cold hemoglobinuria (PCH) is a rare hemolytic anemia triggered by cold exposure.
    • PCH is often associated with specific autoantibodies, such as cold-warm serum lysins with anti-Tja activity.

    Purpose of the Study:

    • To describe two pediatric cases of paroxysmal cold hemoglobinuria (PCH).
    • To report the successful application of compatible transfusion therapy in managing PCH.
    • To highlight the role of cold-warm serum lysins with anti-Tja activity in PCH.

    Main Methods:

    • Case report of two children diagnosed with PCH.
    • Identification of cold-warm serum lysins with anti-Tja activity in both patients.
    • Administration of compatible frozen-thawed red blood cell transfusions during the acute hemolytic phase.

    Related Experiment Videos

    Main Results:

    • Both children presented with PCH associated with cold-warm serum lysins exhibiting anti-Tja activity.
    • Transfusion with compatible frozen-thawed red blood cells successfully managed the acute hemolytic crisis in both cases.
    • This represents the first documented instance of successful compatible transfusion therapy for PCH.

    Conclusions:

    • Compatible frozen-thawed red blood cell transfusion is an effective therapeutic strategy for managing acute hemolytic episodes in PCH.
    • The findings underscore the importance of identifying specific autoantibody activity in PCH for guiding transfusion decisions.
    • This study provides critical evidence for the successful use of transfusion support in PCH patients.