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Inhibition of immune responses in vitro by specific antiserums to Ia antigens

J A Frelinger, J E Niederhuber, D C Shreffler

    Science (New York, N.Y.)
    |April 18, 1975
    PubMed

    Mouse antiserums prepared against Ia antigens, which are products of I (immune response) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.

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