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[Tri-Regol and its application in gynecological practice]
Akusherstvo I Ginekologiia
|February 24, 2001
Summary
Tri-Regol, a contraceptive preparation, demonstrated excellent contraceptive efficacy with a Pearl Index of 0, meaning no pregnancies occurred in 149 cycles. Side effects like breakthrough bleeding were minimal and decreased over time, making it a suitable alternative for women seeking reliable contraception.
Area of Science:
- Gynecology
- Reproductive Health
- Pharmacology
Background:
- Breakthrough bleeding and spotting are common side effects of low-dosed estrogen monophasic oral contraceptives.
- Selective progestin use in oral contraceptives requires evaluation for efficacy and tolerability.
Purpose of the Study:
- To assess the contraceptive and therapeutic benefits of Tri-Regol as an alternative to monophasic oral contraceptives.
- To evaluate Tri-Regol's effectiveness in managing breakthrough bleedings and spotting.
Main Methods:
- A study involving 29 non-smoking women (ages 19-28, nulliparous) over 4-6 months (149 cycles).
- Monitoring for breakthrough bleeding, spotting, and pregnancy rates.
- Assessing ovulation restoration post-discontinuation.
Main Results:
- Zero pregnancies were recorded, yielding a Pearl Index of 0.
- Initial breakthrough bleeding (17.2%) and spotting (6.8%) decreased significantly by the third month (3.4% breakthrough bleeding).
- Ovulation was restored in all patients within three months of discontinuing Tri-Regol.
Conclusions:
- Tri-Regol offers high contraceptive security and effective menstrual cycle control.
- The preparation is well-tolerated, with rare and diminishing side effects.
- Tri-Regol is recommended for nulliparous women and those experiencing persistent breakthrough bleeding with other low-dosed monophasic contraceptives.