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Updated: Aug 2, 2026
10:48
Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression
Published on: May 15, 2014
[Protective effect of vaccination against chickenpox]
V Plesník1, V Príkazský, L Pĕtvaldská
1Krajská hygienická stanice, Ostrava.
Summary
This study assessed the protective effect of the varicella vaccine in adolescents. While some vaccinated individuals contracted chickenpox after exposure, no further cases occurred in the following three years.
Area of Science:
- Virology
- Immunology
- Vaccinology
Context:
- Assessing the long-term efficacy of the varicella vaccine (Oka strain) in adolescents.
- Evaluating vaccine effectiveness following close exposure to varicella-infected individuals.
Purpose:
- To determine the duration of protective immunity conferred by the varicella vaccine.
- To identify factors influencing vaccine failure in adolescents.
Summary:
- A cohort of 310,000 person-days was monitored in adolescents (13-17 years) vaccinated with a live attenuated Oka virus vaccine.
- Six of 55 vaccinated subjects exposed to varicella cases contracted the disease, particularly those with low antibody levels after a single dose.
- No further varicella cases were observed in the subsequent three years, suggesting sustained protection.
Impact:
- Provides evidence for the sustained protective effect of varicella vaccination in adolescents.
- Highlights the importance of adequate antibody levels for vaccine efficacy.
- Informs public health strategies for varicella prevention programs.
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