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Related Experiment Videos

Stability of cefotaxime sodium in solid state.

M Zajac1, W Musiał, L Pawłowski

  • 1Department of Pharmaceutical Chemistry, University of Medical Sciences, Poznań, Poland.

Die Pharmazie
|February 24, 2001
PubMed
Summary

The stability of cefotaxime sodium solid-state was studied under varying temperature and humidity. Decomposition kinetics and thermodynamics were analyzed using HPLC, revealing key degradation insights.

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Area of Science:

  • Pharmaceutical Sciences
  • Physical Chemistry
  • Analytical Chemistry

Background:

  • Cefotaxime sodium is a crucial third-generation cephalosporin antibiotic.
  • Understanding its solid-state stability is vital for drug formulation and storage.
  • Environmental factors like temperature and humidity significantly impact drug degradation.

Purpose of the Study:

  • To investigate the influence of temperature and relative humidity on cefotaxime sodium's solid-state stability.
  • To determine the kinetic and thermodynamic parameters governing the decomposition of cefotaxime sodium.
  • To provide data for optimizing storage conditions and predicting shelf-life.

Main Methods:

  • Solid-state stability studies were conducted under controlled temperature and relative humidity conditions.
  • High-Performance Liquid Chromatography (HPLC) with UV detection was employed to quantify cefotaxime sodium.
  • Kinetic analysis (e.g., reaction order, rate constants) and thermodynamic calculations (e.g., activation energy) were performed.

Main Results:

  • Degradation of cefotaxime sodium was observed to be dependent on both temperature and relative humidity.
  • Kinetic parameters characterizing the decomposition rate were successfully calculated.
  • Thermodynamic parameters provided insights into the energy requirements for the degradation process.

Conclusions:

  • Temperature and relative humidity are critical factors affecting cefotaxime sodium's solid-state stability.
  • The study provides essential kinetic and thermodynamic data for cefotaxime sodium degradation.
  • Findings can inform pharmaceutical development, ensuring the quality and efficacy of cefotaxime sodium formulations.

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