[Formation of a secondary adrenaline-heparin-fibrinogen complex and its properties]

An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen. After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex