Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat
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Updated: Oct 9, 2026

Dissection of Pelvic Autonomic Ganglia and Associated Nerves in Male and Female Rats
Published on: March 7, 2020
Q P Ma1, R Hill, D Sirinathsinghji
1Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK.
Abstract:
The bradykinin B1 receptor is thought to be induced by tissue injury and inflammation. In the present study, we have investigated whether there is a basal expression of B1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B1-immunoreactive in rats. Both small and medium-sized DRG neurons were B1-immunoreactive, suggesting that they are likely to be Adelta- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B1 receptors in the modulation of nociceptive sensory transmission.
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