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Human lung fructose-1,6-bisphosphatase is localized in pneumocytes II
A Gizak1, D Rakus, J Kolodziej
1Department of Animal Physiology, Institute of Zoology, Wroclaw University, Poland.
Histology and Histopathology
|February 24, 2001
Abstract:
The localization of fructose-1,6-bisphosphatase (Fru-1,6-Pase EC 3.1.3.11) in human alveolar epithelium was determined immunohistochemically using a polyclonal antibody raised against the enzyme purified from human liver. The immunohistochemical analysis revealed that the Fru-1,6-Pase was localized in pneumocytes II and was absent in pneumocytes I. Hypothetically Fru-1,6-Pase participating in glucose-6-phosphate synthesis from noncarbohydrate precursors increases NADPH level which is used for surfactant synthesis and for glutathione redox cycle.