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Two cases of ectopic hamartomatous thymoma
C Zhao1, T Yamada, S Kuramochi
1Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
Virchows Archiv : an International Journal of Pathology
|February 24, 2001
Summary
Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm. This study reports two cases, noting massive myoid cells and their potential epithelial origin, adding to the understanding of this rare tumor.
Area of Science:
- Pathology
- Oncology
Background:
- Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm.
- Only 24 cases have been reported since its naming in 1984.
Observation:
- Two cases of EHT were analyzed, with one exhibiting massive myoid cells.
- Typical EHT features include epithelial cell nests, dominant spindle cells, and intermingled adipose cells.
Findings:
- Massive myoid cells and a transition from spindle epithelial cells to myoid cells were observed in one case.
- Immunohistochemistry revealed spindle cells positive for cytokeratin and EMA.
- Myoid cells expressed cytokeratin, EMA, myoglobin, and creatine kinase-mm.
Implications:
- The findings suggest myoid cells in EHT may originate from epithelial cells.
- This indicates a potential intermediate state between epithelial and muscular cells within EHT.