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Updated: Jul 29, 2026
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
[History of nephrectomy]
N Al-Khalil1, P Panchev, Kh Kumanov
1Government University Hospital "Aleksandrovska," Department of Urology, Sofia, Bulgaria.
Khirurgiia
|February 24, 2001
Summary
Removing a single kidney is not fatal if the other functions, a fact established through early experiments and human cases. This historical overview traces nephrectomy development, including its decline in favor of organ-sparing techniques and the rise of laparoscopic nephrectomy.
Area of Science:
- Nephrology
- Surgical History
- Urology
Background:
- Early animal experiments and accidental human nephrectomies established that survival is possible with a single functioning kidney.
- The first routine nephrectomy was performed by Gustav Simon in 1869, marking a significant point in surgical history.
Observation:
- The development of nephrectomy, both globally and in Bulgaria, is traced from the late 19th century.
- Initially a common procedure, nephrectomy rates decreased with advancements in diagnostic techniques, leading to more organ-sparing interventions.
Findings:
- Nephrectomy was a frequent kidney operation in the early 20th century but saw reduced application later.
- Laparoscopic nephrectomy, introduced in the 1990s, is a safe option for malignant renal pathology and selected urological conditions.
Implications:
- The evolution of nephrectomy reflects progress in surgical techniques and diagnostic capabilities.
- Laparoscopic nephrectomy represents a modern, minimally invasive approach to kidney removal, expanding treatment options for renal diseases.
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