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Updated: Jul 19, 2026
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Aldosterone in renal disease.
T H Hostetter1, M E Rosenberg, H N Ibrahim
1University of Minnesota, Division of Renal Diseases and Hypertension, Minneapolis 55455, USA. hoste002@tc.umn.edu
Current Opinion in Nephrology and Hypertension
|February 24, 2001
Summary
Blocking the renin-angiotensin-aldosterone system slows kidney disease progression. Both angiotensin II and aldosterone contribute to kidney damage and hypertension, highlighting the importance of this system in renal disease.
Area of Science:
- Nephrology
- Endocrinology
- Cardiovascular Research
Background:
- Renin-angiotensin-aldosterone system (RAAS) blockade is effective in slowing renal disease progression.
- Angiotensin II plays a key role in kidney disease progression through hemodynamic and non-hemodynamic effects.
Purpose of the Study:
- To investigate the role of aldosterone in addition to angiotensin II in sustaining kidney disease.
- To evaluate the impact of RAAS-blocking drugs on aldosterone levels.
Main Methods:
- Studies predominantly utilized the remnant kidney model.
- Analysis of drug effects on hormone levels and renal pathology.
Main Results:
- RAAS blockade effectively retards experimental and human renal disease progression.
- Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers lower aldosterone levels.
- Both angiotensin II and aldosterone are crucial in maintaining hypertension and kidney damage.
Conclusions:
- Aldosterone, alongside angiotensin II, is integral to the progression of renal disease.
- Targeting the RAAS, including aldosterone, is vital for managing progressive kidney diseases.
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