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Related Experiment Videos

Serum prolactin patterns in early human gestation.

J M Barberia, S Abu-Fadil, O A Kletzky

    American Journal of Obstetrics and Gynecology
    |April 15, 1975
    PubMed
    Summary
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    Human prolactin (HPRL) levels rise after conception, mirroring estradiol patterns in early pregnancy. High estrogen levels appear to influence HPRL secretion in women.

    Area of Science:

    • Reproductive Endocrinology
    • Hormone Physiology
    • Maternal Health

    Background:

    • Understanding early pregnancy hormonal changes is crucial for reproductive health.
    • Human prolactin (HPRL) plays a role in reproduction, but its precise dynamics around conception require further elucidation.
    • Estradiol and other protein hormones are key regulators during the menstrual cycle and early gestation.

    Purpose of the Study:

    • To determine the relationship between human prolactin (HPRL), other protein hormones, and estradiol levels.
    • To track these hormonal changes in serum immediately before and during the initial weeks following conception.
    • To investigate the temporal patterns of HPRL in relation to the luteinizing hormone (LH) peak and early gestation.

    Main Methods:

    • Radioimmunoassay (RIA) was employed to measure HPRL concentrations.

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  • Serum samples were collected daily from women during their conception cycle and for several weeks post-conception.
  • Hormonal profiles, including estradiol and human placental lactogen, were analyzed and compared with HPRL patterns.

    • Main Results:

    • HPRL concentration was observed to increase above non-pregnant levels 32 to 36 days after the luteinizing hormone (LH) peak.
    • The patterns of estradiol and HPRL showed similarity in early gestation.
    • No similarity was found between the patterns of HPRL and human placental lactogen.

    Conclusions:

    • Early gestation is characterized by an increase in HPRL levels, commencing around 32-36 days post-LH peak.
    • Estradiol and HPRL exhibit parallel changes during early pregnancy, suggesting a potential interplay.
    • Findings support the established understanding that elevated estrogen levels positively influence HPRL secretion in humans.