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Related Experiment Videos

Contraceptive vaginal rings.

B Harwood1, D R Mishell

  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213-3180, USA.

Seminars in Reproductive Medicine
|December 1, 2001
PubMed
Summary
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Contraceptive vaginal rings (CVRs) offer a safe and effective alternative to oral contraceptives (OCs). These rings provide consistent hormone delivery, improving user convenience and bioavailability.

Area of Science:

  • Reproductive endocrinology
  • Pharmacology
  • Drug delivery systems

Background:

  • Contraceptive vaginal rings (CVRs) deliver sex steroids directly through the vaginal epithelium.
  • This method bypasses the first-pass metabolism in the liver, unlike oral contraceptives (OCs).

Purpose of the Study:

  • To evaluate the efficacy, safety, and user experience of contraceptive vaginal rings.
  • To compare CVRs with oral contraceptives in terms of hormonal delivery and patient adherence.

Main Methods:

  • Analysis of large clinical trials involving progestin-only and combined estrogen-progestin CVRs.
  • Assessment of efficacy, safety profiles, and continuation rates compared to OCs.

Main Results:

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  • Progestin-only CVRs demonstrated good efficacy and safety for 3-6 months of continuous use.
  • Combined estrogen-progestin CVRs showed typical-use efficacy comparable to OCs with acceptable bleeding patterns.

    • Conclusions:

    • CVRs offer advantages like constant serum steroid levels and improved bioavailability.
    • Continuation rates for CVRs are similar to OCs, indicating user acceptance and convenience.