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Updated: Oct 9, 2026

Super-resolution Imaging of Proteus mirabilis Biofilm by Expansion Microscopy
Published on: July 18, 2025
[Biosynthesis of Proteus mirabilis nuclease]
Z Z Salikhova1, R B Sokolova, D V Iusupova
1Kazan State University, ul. Lenina 18, Kazan, 420008 Russia.
Abstract:
The culture liquid and periplasm of Proteus mirabilis contained nuclease, an enzyme with DNase and RNase activities. The nuclease was most actively synthesized in the early exponential and stationary growth phases. Nuclease synthesis was regulated by nucleic acids (induction by substrate) and inorganic phosphate (end-product inhibition). The synthesis and secretion of nuclease by P. mirabilis was induced by mitomycin C, an inducer of the SOS functions of cells. This suggests the involvement of SOS-response proteins in the regulation of nuclease synthesis.
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