[Differential diagnosis of oxyphilic (Hürthle cell) adenomas and carcinomas of the thyroid]

Successful application of a double immunostaining of oxyphilic tumors with a specific antimitochondrial antibody and proliferative marker Ki-67 was made for the first time. Comparative study of proliferative activity did not show a statistically significant difference between Hurthle-cell adenomas and carcinomas. However, oxyphilic carcinomas had a statistically significant positive correlation between proliferative index and aggressive course of tumor, tendency to recurrence, high metastatic activity, tumor size, presence of necrosis and capsule penetration.