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Updated: Jul 15, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Animal models in alcohol research.

B Tabakoff¹, P L Hoffman

¹Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, USA.

Alcohol Research & Health : the Journal of the National Institute on Alcohol Abuse and Alcoholism

|February 24, 2001

Summary

Animal models are crucial for studying alcohol use and dependence, offering insights into genetics and behavior not possible in humans. Researchers carefully consider species, administration methods, and validity when using these vital research tools.

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Area of Science:

Neuroscience
Pharmacology
Genetics

Background:

Animal models are indispensable for investigating alcohol use, abuse, and dependence.
They enable research methodologies not feasible in human subjects.
These models are key to understanding complex alcohol-related phenomena.

Purpose of the Study:

To explore the utility of animal models in alcohol research.
To examine various aspects of alcohol use and dependence studied in animals.
To highlight the genetic research potential of animal models.

Main Methods:

Development of specialized animal models for alcohol research.
Genetic manipulation of animal subjects to study alcoholism determinants.
Controlled administration of alcohol to animal subjects.

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Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

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Last Updated: Jul 15, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Main Results:

Animal models effectively replicate alcohol-seeking behavior and dependence.
They are instrumental in studying alcohol-induced organ damage and tolerance.
Genetically modified animal models provide insights into the genetic basis of alcoholism.

Conclusions:

Animal models are essential for advancing our understanding of alcohol use disorders.
Careful consideration of model selection (species, administration) and validity is critical.
These models facilitate comprehensive research into the biological and behavioral aspects of alcoholism.