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Related Experiment Video

Updated: Jul 17, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Animal models of psychiatric disorders and their relevance to alcoholism.

R Hitzemann1

  • 1Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon, USA.

Alcohol Research & Health : the Journal of the National Institute on Alcohol Abuse and Alcoholism
|February 24, 2001
PubMed
Summary

Animal models are crucial for studying psychiatric disorders like alcoholism, enabling research not possible in humans. These validated models help understand co-occurring conditions and improve treatment strategies for patients.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Animal models are essential for psychiatric disorder research, particularly alcoholism, due to ethical limitations in human studies.
  • Developing and validating animal models allows for rigorous investigation of complex human behaviors and disorders.
  • Existing models for schizophrenia, anxiety, depression, and alcoholism are vital for studying comorbidities.

Purpose of the Study:

  • To review the development and application of animal models in psychiatric research.
  • To highlight the role of these models in understanding alcoholism and its relationship with other psychiatric disorders.
  • To explore how animal models can inform clinical treatment strategies for complex cases.

Main Methods:

  • Review of established methodologies for validating animal models of psychiatric disorders.

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Last Updated: Jul 17, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
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Published on: January 7, 2019

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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  • Analysis of research utilizing animal models to investigate alcoholism and comorbid conditions.
  • Synthesis of findings on the reliability and applicability of animal models in translational research.

    • Main Results:

    • Numerous validated animal models exist for key psychiatric disorders, including alcoholism.
    • These models facilitate the study of the relationship between alcoholism and co-occurring psychiatric conditions.
    • The use of animal models is advancing the understanding of underlying mechanisms and potential therapeutic targets.

    Conclusions:

    • Animal models are indispensable tools for advancing psychiatric research, especially for alcoholism.
    • Validated animal models provide critical insights into the etiology and treatment of psychiatric comorbidities.
    • Continued development and application of these models promise to improve patient care and treatment outcomes.