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Related Experiment Videos

Glue-sniffing neuropathy.

R Korobkin, A K Asbury, A J Sumner

    Archives of Neurology
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Inhaling n-hexane from contact cement vapors can cause toxic peripheral neuropathy. This condition is characterized by specific nerve damage and improves when exposure to n-hexane ceases.

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    Area of Science:

    • Neurology
    • Toxicology
    • Occupational Health

    Background:

    • Industrial exposure to n-hexane is a known cause of neuropathy.
    • The neurotoxicity of n-hexane in commercial contact cement vapors is less recognized.

    Purpose of the Study:

    • To report a case of peripheral neuropathy linked to n-hexane inhalation from contact cement.
    • To describe the clinical, electrophysiological, and pathological features of this neuropathy.

    Main Methods:

    • Case study of a young man with a history of glue-sniffing.
    • Clinical assessment and nerve biopsy (radial cutaneous nerve).
    • Electrophysiological studies (nerve conduction velocities).

    Main Results:

    • The patient developed severe distal symmetrical polyneuropathy after using n-hexane-containing cement.

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  • Nerve biopsy revealed axonal swelling with neurofilamentous masses and myelin thinning.
  • Nerve conduction velocities were slow, consistent with neuropathy.
  • Symptoms improved after switching to n-hexane-free cement.

    • Conclusions:

    • Excessive inhalation of n-hexane from contact cement solvents can be neurotoxic.
    • This n-hexane-induced neuropathy exhibits distinct electrophysiological and pathological characteristics.