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In Vitro System for Measuring Chordal Force Changes Following Mitral Valve Patch Repair.

B Ostli1, J Vester-Petersen1, J B Askov2

  • 1Dept. of Biomedical Engineering, Engineering College of Aarhus, Aarhus, Denmark.

Cardiovascular Engineering and Technology
|August 15, 2015
PubMed
Summary
This summary is machine-generated.

This study developed a novel system to measure chordae tendineae forces in mitral valve repairs. The system accurately reflects how patch augmentation affects stress distribution in the mitral valve leaflet.

Keywords:
In vitroMitral valvebiomechanicsforceleft ventricle

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Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Biomechanical Analysis

Background:

  • Mitral valve repair techniques are continually being optimized.
  • Patch augmentation is a key strategy for complex mitral valve repairs, addressing issues like functional mitral regurgitation and systolic anterior motion.
  • Understanding stress redistribution in valve leaflets after patch augmentation is crucial.

Purpose of the Study:

  • To describe a novel system for investigating chordae tendineae tension redistribution after mitral valve patch augmentation.
  • To assess how patch augmentation alters stress distribution within the mitral valve leaflet.
  • To establish a method for measuring secondary chordae tendineae forces in relation to applied pressure.

Main Methods:

  • An in vitro test setup was created using native porcine mitral valves, including an annulus and papillary muscle positioning system.
  • The system allowed for visualization of patch augmentation effects from both atrial and ventricular perspectives.
  • Chordae tendineae forces were measured under regulated ventricular pressure (0-150 mmHg) after applying a pericardial patch to the anterior mitral leaflet.

Main Results:

  • The test setup successfully accommodated native porcine mitral valves and simulated clinical patch repairs.
  • A strong correlation (R² = 0.95) was observed between secondary chordae tendineae forces and applied transvalvular pressure.
  • The system demonstrated the ability to maintain normal mid-systolic mitral valve function and visual access.

Conclusions:

  • The developed test setup is effective for measuring secondary chordae forces and the pressure-force relationship in mitral valve repairs.
  • This system allows for the identification of shifts in secondary chordae insertion points on the anterior leaflet relative to the coaptation zone.
  • The findings support the use of this system to better understand the biomechanical consequences of patch augmentation in mitral valve repair.