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Updated: Jun 27, 2026

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A Trends Analysis and Scoping Review: Minimal Invasive Extracorporeal Circulation.

Doğuş Hemşinli¹, Sedat Ozan Karakişi¹, Hülya Kılıç²

¹Faculty of Medicine, Department of Cardiovascular Surgery, Recep Tayyip Erdoğan University, Rize, Türkiye.

Cardiovascular Engineering and Technology

|June 25, 2026

Summary

This summary is machine-generated.

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Minimal invasive extracorporeal circulation (MiECC) research shows improved organ protection and reduced transfusions compared to conventional cardiopulmonary bypass (cCPB). While not demonstrating mortality benefits, MiECC research has evolved significantly, focusing on patient outcomes and organ function.

Area of Science:

Cardiovascular Surgery
Medical Technology
Research Trends Analysis

Background:

Minimal invasive extracorporeal circulation (MiECC) was developed as a biocompatible alternative to conventional cardiopulmonary bypass (cCPB).
The aim of MiECC is to mitigate hemodilution, reduce systemic inflammatory response, and enhance organ protection.
Despite growing evidence over 30 years, a systematic mapping of MiECC research evolution and outcomes is lacking.

Purpose of the Study:

To analyze temporal, geographical, methodological, and clinical trends in MiECC research from 1990 to 2025.
To systematically map the evolution of research activity and its results in the field of MiECC.
To identify shifts in research focus and reported outcomes over time.

Main Methods:

A comprehensive search of major databases (PubMed/MEDLINE, Web of Science, Scopus, Cochrane) up to September 2025.

Keywords:

Bibliometrics Cardiopulmonary bypass Extracorporeal circulation MiECC Mini cardiopulmonary bypass Mini-CPB Miniaturized extracorporeal circulation Minimal extracorporeal circulation Minimal ınvasive extracorporeal circulation Trend analysis

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Last Updated: Jun 27, 2026

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

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Published on: January 17, 2025

Inclusion of studies with original human clinical data (RCTs, cohort studies, observational reports, protocol papers) reporting perioperative or clinical outcomes.

Exclusion of reviews, meta-analyses, editorials, animal studies, and conference abstracts lacking full text; data extraction by two independent reviewers.

Main Results:

128 studies met eligibility criteria, with publication activity increasing substantially after 2002 and peaking in 2021.
European centers, particularly Germany and Italy, were major contributors; methodological/protocol papers and RCTs predominated.
Research focus shifted from transfusion/inflammatory markers to renal function, neurological complications, and survival, with benefits noted in elderly, renal dysfunction, and low EF patients.

Conclusions:

MiECC research has advanced from feasibility studies to large multicenter trials.
Evidence supports reduced transfusion needs, attenuated inflammatory response, and improved organ protection with MiECC.
No clear mortality benefit has been demonstrated, but research shows progress in patient outcomes.