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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...

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Correction: Luca et al. Global and Regional Diagnostic Results of Progress Toward Cervical Cancer Elimination, According to the WHO Strategy: A Systematic Literature Review with Narrative Synthesis. <i>Diagnostics</i> 2026, <i>16</i>, 1224.

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Related Experiment Video

Updated: May 28, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Indirect Estimation of 25-Hydroxyvitamin D Reference Intervals Using Data Mining.

Esra Yılmaz1, Hülya Kılıç2

  • 1Clinical Biochemistry Laboratory, Karabük Training and Research Hospital, Karabuk 78200, Türkiye.

Diagnostics (Basel, Switzerland)
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Establishing local, population-specific vitamin D reference intervals using the refineR algorithm is crucial. This method offers improved accuracy over traditional approaches, aiding in the early diagnosis of vitamin D-related disorders.

Keywords:
25-hydroxyvitamin Ddata miningreference rangereference value

Related Experiment Videos

Last Updated: May 28, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Area of Science:

  • Clinical Biochemistry
  • Endocrinology
  • Laboratory Medicine

Background:

  • Vitamin D reference intervals are affected by seasonality and population specifics.
  • Existing intervals may not accurately reflect local populations.
  • Accurate vitamin D levels are essential for diagnosing metabolic and skeletal disorders.

Purpose of the Study:

  • To establish local, population-specific 25-hydroxyvitamin D reference intervals.
  • To compare the refineR algorithm with the non-parametric method for interval calculation.
  • To assess the impact of age and sex on vitamin D levels.

Main Methods:

  • Retrospective analysis of 127,220 laboratory results (2022-2025).
  • Data filtered for adult, morning fasting, outpatient samples with normal PTH.
  • 24,036 eligible results stratified by age and sex; analyzed using refineR and non-parametric methods.

Main Results:

  • Vitamin D levels showed a right-skewed distribution (Median: 12.92 ng/mL).
  • refineR yielded lower upper reference limits compared to the non-parametric method.
  • Vitamin D levels increased with age; females aged 18-40 had the lowest levels. Summer concentrations were highest.

Conclusions:

  • The refineR algorithm is more effective at handling outliers and pathological results.
  • Age- and sex-specific reference intervals are clinically necessary.
  • Population-specific intervals improve diagnostic accuracy for vitamin D deficiency and related disorders.