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Updated: Aug 10, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis
M D Wooten1, G V Reddy, R D Johnson
1Sections of Rheumatology and Cardiology, Department of Veterans Affairs Regional Medical Center, Wilmington, Delaware,USA.
Abstract:
A 57-year-old man with nodular rheumatoid arthritis was started on a combination of etanercept and methotrexate. After treatment for five months on this therapy, he presented with new-onset atrial fibrillation. While this report is anecdotal, any new drug warrants intense monitoring for unexpected toxicities in the post-marketing period. Etanercept is being tried in patients with congestive heart failure, where TNF-a seems to be increased. Further surveillance and caution are suggested in patients with known coronary artery disease or atrial dysrhythmia.
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