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Eluxadoline-Associated Pancreatitis in a Post-Cholecystectomy Patient: A Case Report
Delaware Medical Journal
|June 13, 2018
Summary
Eluxadoline effectively treats irritable bowel syndrome with diarrhea (IBS-D). However, rare cases of eluxadoline-induced pancreatitis and sphincter of Oddi dysfunction (SOD) have been reported, particularly in post-cholecystectomy patients.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Eluxadoline is an FDA-approved medication for diarrhea-predominant irritable bowel syndrome (IBS-D).
- It acts as a mixed mu-opioid receptor agonist and delta-opioid receptor antagonist in the gastrointestinal tract.
- Previous clinical trials (IBS-3001/3002) noted sphincter of Oddi dysfunction (SOD) and acute pancreatitis in a small number of patients.
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