[Production of immune mediators, induced by Lassa virus, in a human mononuclear cell culture]

Infection of human mononuclear cells with Lassa virus leads to production of inflammatory cytokines (tumor necrosis factor and interleukin-1). These cytokines cause expression of adhesion receptors ICAM-1 and VCAM-1 by human endothelial cells. Mitogen-induced cell proliferation was not suppressed 1 h after infection of human mononuclear cells with Lassa virus in a dose of 0.01 PFU/cell. The capacity of cells to proliferation in response to mitogen stimulation decreased significantly only 4 h after infection.