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Spray-dried microspheres containing ketoprofen formulated into capsules and tablets
M D Moretti1, E Gavini, C Juliano
1Dipartimento di Scienze del Farmaco, Università di Sassari, Italy.
Journal of Microencapsulation
|February 24, 2001
Summary
Spray-drying ketoprofen with cellulose derivatives created microparticles for oral NSAID delivery. Formulations in capsules or tablets allow for rapid or prolonged drug release, offering versatile administration options.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Developing effective oral drug delivery systems for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is crucial for patient compliance and therapeutic outcomes.
- Ketoprofen, a widely used NSAID, requires optimized formulations to ensure stability and controlled release.
Purpose of the Study:
- To prepare and characterize ketoprofen-loaded microparticles using spray-drying with cellulose acetate butyrate (CAB) and hydroxypropylmethylcellulose phthalate (HPMCP).
- To evaluate the in vitro drug release profiles of microparticle formulations (capsules and tablets) at different pH levels.
- To assess the suitability of these microparticle formulations for oral NSAID administration.
Main Methods:
- Microspheres were fabricated via spray-drying using ketoprofen and varying weight ratios of CAB and HPMCP at 3%, 6%, and 9% w/v concentrations.
- Characterization included scanning electron microscopy (SEM) for shape, light scattering for size, production yield, and encapsulation efficiency.
- In vitro release studies were conducted in acidic and neutral pH conditions for both capsule and direct-compression tablet formulations.
Main Results:
- Spray-drying successfully produced ketoprofen-loaded microparticles with varying characteristics based on polymer ratios and concentrations.
- Microparticle formulations, when encapsulated or compressed into tablets, demonstrated tunable drug release kinetics.
- Both rapid and prolonged release profiles were achieved, dependent on the final dosage form (capsules vs. tablets).
Conclusions:
- Spray-drying of ketoprofen with cellulose derivative blends yields microparticles suitable for oral drug delivery.
- The choice of formulation (capsule or tablet) significantly influences the drug release rate, enabling tailored therapeutic delivery.
- These microparticle formulations present a promising approach for the oral administration of NSAIDs like ketoprofen.