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Updated: Aug 18, 2026
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
[Effects of verapamil and gynipral on the uterine contractile activity in rats]
O V Kaplenko1, V V Korkhov, E A Lesik
1Laboratory of Pharmacology, Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleevskaya Liniya 3, St. Petersburg, 199034 Russia.
Abstract:
Verapamil and gynipral administered to pregnant rats in doses on a clinical level suppress the uterine contractions, which is manifested by a decrease in the amplitude and frequency of the biopotential. The joint administration of gynipral and verapamil (in half doses) resulted in a pronounced tocolytic effect.
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