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Vasospastic angina accompanied by Brugada-type electrocardiographic abnormalities
1First Department of Internal Medicine, Niigata University School of Medicine, Japan. chinushi@med.niigata-u.ac.jp
Journal of Cardiovascular Electrophysiology
|February 24, 2001
Summary
This study highlights the link between Brugada syndrome and vasospastic angina. Coexistence of these conditions may increase susceptibility to ventricular fibrillation, necessitating further clinical investigation.
Area of Science:
- Cardiology
- Electrophysiology
- Internal Medicine
Background:
- Brugada syndrome is characterized by specific ECG abnormalities and an increased risk of sudden cardiac death.
- Vasospastic angina involves reversible coronary artery constriction, leading to myocardial ischemia.
- The interplay between these two conditions is not well understood.
Observation:
- Two patients presented with both vasospastic angina and Brugada-type ECG abnormalities.
- Symptoms included chest pain and syncopal episodes, with ECG showing ST elevation and right bundle branch block patterns.
- Coronary angiography revealed no obstructive coronary artery disease in one patient, while the other experienced acetylcholine-induced vasospasm.
Findings:
- ECG abnormalities characteristic of Brugada syndrome were present at rest and accentuated by Class I antiarrhythmic drugs.
- Programmed electrical stimulation induced ventricular fibrillation in both patients.
- The study highlights a potential interplay between coronary vasospasm and Brugada syndrome.
Implications:
- The coexistence of vasospastic angina and Brugada syndrome may modulate susceptibility to ventricular fibrillation.
- Further research is needed to elucidate the clinical significance and management of patients with both conditions.
- Recognizing this association is vital for accurate diagnosis and therapeutic interventions.