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Related Experiment Videos

Risperidone-induced cholestatic hepatitis.

S Krebs1, H Dormann, U Muth-Selbach

  • 1Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nuremberg, Germany. krebs@pharmakologie.uni-erlangen.de

European Journal of Gastroenterology & Hepatology
|February 24, 2001
PubMed
Summary
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Risperidone, an antipsychotic, can cause liver injury. Monitoring liver function and cholestatic parameters is crucial during risperidone treatment, especially in the initial weeks.

Area of Science:

  • Hepatology
  • Pharmacology
  • Psychiatry

Background:

  • Risperidone is an atypical antipsychotic drug.
  • It is generally considered to have a lower risk of hepatic side-effects compared to phenothiazine antipsychotics.

Observation:

  • A case of a 37-year-old male patient with paranoid psychosis treated with risperidone was observed.
  • The patient experienced a rapid increase in liver enzymes and cholestatic parameters.

Findings:

  • Diagnostic work-up excluded other potential causes of liver injury.
  • Percutaneous liver biopsy confirmed drug-induced liver injury and cholestasis.
  • Liver function tests normalized within one month after discontinuing antipsychotic treatment.

Implications:

Related Experiment Videos

  • This case highlights the potential for risperidone to cause cholestatic hepatotoxicity.
  • Monitoring cholestatic parameters alongside liver function enzymes is recommended during risperidone initiation.
  • Further research may be needed to understand the incidence and risk factors for risperidone-induced liver injury.