[Pneumocystis carinii pneumonia in a child without immunodepression]

O Jadot1, D Rocour-Brumioul, J Senterre

  • 1Service de Pédiatrie, Université de Liège.

Revue Medicale De Liege
|February 24, 2001
PubMed

Insights

A 5-month-old infant was diagnosed with Pneumocystis pneumonia despite lacking immunosuppression. This case highlights the need to consider Pneumocystis pneumonia in infants, even without typical risk factors.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pulmonology

Background:

  • Pneumocystis pneumonia (PCP) is typically associated with severe immunosuppression.
  • Atypical presentations of PCP can occur, particularly in infants.
  • Early diagnosis and treatment are crucial for favorable outcomes.

Observation:

  • A 5 1/2 month old infant presented with atypical pneumonia symptoms.
  • Polymerase Chain Reaction (PCR) testing confirmed Pneumocystis carinii pneumonia.
  • Further investigations did not reveal any underlying immunosuppression in the infant.

Findings:

  • The diagnosis of Pneumocystis carinii pneumonia was established via PCR.
  • The absence of immunosuppression in this infant challenges typical etiological assumptions for PCP.
  • This case underscores that Pneumocystis pneumonia can manifest atypically.

Implications:

  • This case broadens the differential diagnosis for pneumonia in infants, irrespective of immune status.
  • It emphasizes the importance of considering Pneumocystis pneumonia in non-immunocompromised infants.
  • Further research into non-immunosuppressive factors contributing to PCP is warranted, especially in pediatric populations.

Related Concept Videos

Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...