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Updated: Aug 10, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
Microchip-based synthesis and analysis: control of multicomponent reaction products and intermediates
M C Mitchell1, V Spikmans, A J de Mello
1AstraZeneca/SmithKline Beecham Centre for Analytical Science, Imperial College of Science, Technology and Medicine, Department of Chemistry, Exhibition Road, South Kensington, London, UK SW7 2AY.
Abstract:
A miniaturised-SYNthesis and Total Analysis System (mu SYNTAS) was used for the solution-phase synthesis and on-line analysis (TOF-MS) of Ugi multicomponent reaction (MCR) products. This approach provides an unusually high degree of control of the MCR and delivers detailed, novel information on reaction intermediates in real-time. Specifically, the Ugi 4 component condensation (4CC) involving the reaction of an amine, acid, aldehyde and isocyanide species was performed at room temperature in a controllable fashion. Furthermore, observation of the nitrilium intermediate, cyclohexyl(2-piperidin-1-ylethylidyne)ammonium chloride, is presented for the first time.
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