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Related Experiment Videos

Cross-talk between enteric pathogens and the intestine.

S Uzzau1, A Fasano

  • 1Dipartimento di Scienze Biomediche, Sassari, Italy.

Cellular Microbiology
|February 24, 2001
PubMed
Summary

Enteric pathogens use host-like molecules to disrupt intestinal secretion. Bacteria like E. coli, Salmonella, and Vibrio cholerae mimic host signaling to manipulate transcellular and paracellular pathways, causing disease.

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Area of Science:

  • Microbiology
  • Cell Biology
  • Pathogenesis

Background:

  • Enteric pathogens modulate virulence gene expression in response to the intestinal environment.
  • Bacterial strategies for inducing intestinal secretion involve factors mimicking host counterparts.

Purpose of the Study:

  • To review recently discovered bacterial strategies for causing intestinal secretion.
  • To highlight how bacterial factors interfere with host epithelial cell signaling.

Main Methods:

  • Literature review of recent findings on enteric pathogen virulence factors.
  • Analysis of molecular mimicry between bacterial toxins and host signaling molecules.

Main Results:

  • Enterotoxigenic E. coli and enteroaggregative E. coli produce heat-stable enterotoxins (STs) and EAST1, mimicking guanylin to activate cGMP-dependent transcellular secretion.
  • Salmonella elaborates SopB, mimicking host 4-phosphatases to activate Ca-dependent transcellular secretion.
  • Vibrio cholerae produces Zonula occludens toxin (Zot), mimicking host tight junction modulators to activate paracellular secretion.

Conclusions:

  • Bacterial pathogens have evolved sophisticated mechanisms to hijack host signaling pathways for intestinal secretion.
  • Understanding these mimicry strategies is crucial for developing targeted therapies against enteric infections.

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