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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

237
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
237
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

498
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
498

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Related Experiment Video

Updated: Jun 13, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Adaptive Deep Brain Stimulation in Parkinson's Disease: A Delphi Consensus Study.

M Guidetti1, T Bocci1,2, M De Pedro Del Álamo3

  • 1"Aldo Ravelli" Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milan, Italy.

Medrxiv : the Preprint Server for Health Sciences
|September 10, 2024
PubMed
Summary
This summary is machine-generated.

Adaptive Deep Brain Stimulation (aDBS) is poised to become standard practice within a decade, offering safer and more effective treatment for Parkinson's disease. Experts anticipate aDBS will provide faster, stable symptom control compared to conventional DBS.

Keywords:
DBSDeep Brain StimulationDelphi consensusParkinson’s diseaseadaptive DBSclosed-loop DBSmovement disordersneuromodulation

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Area of Science:

  • Neuroscience
  • Neurological Surgery
  • Biomedical Engineering

Background:

  • Conventional Deep Brain Stimulation (cDBS) has evolved significantly, with adaptive approaches (aDBS) representing the next frontier.
  • While aDBS devices are available, data on clinical application and limitations are scarce, necessitating expert consensus.
  • The transition from fixed-rate to on-demand cardiac pacing offers a historical parallel for the expected rise of adaptive neuromodulation.

Purpose of the Study:

  • To gather global expert opinion on the clinical application and technological challenges of adaptive Deep Brain Stimulation (aDBS).
  • To guide and ground the clinical development and practice of aDBS for neurological disorders.
  • To establish consensus on the safety, efficacy, and future trajectory of aDBS.

Main Methods:

  • A Delphi method was employed, involving a 5-point Likert scale questionnaire.
  • Twenty-one experienced Deep Brain Stimulation (DBS) clinicians participated in the study.
  • Forty-two questions covering technical and clinical aspects of aDBS were submitted to the expert panel.

Main Results:

  • Experts reached consensus that aDBS will be integrated into clinical practice within 10 years.
  • The panel agreed on the safety of aDBS and its potential for faster, more stable treatment responses than cDBS.
  • aDBS is expected to benefit Parkinson's disease patients with tremor, motor fluctuations, and dyskinesias, though algorithm optimization is needed.

Conclusions:

  • Adaptive Deep Brain Stimulation (aDBS) is considered safe and holds promise for maximizing effectiveness in Parkinson's disease (PD) patients.
  • Further research is required, particularly in algorithm development and identifying markers for complex PD symptoms.
  • aDBS is anticipated to enter widespread clinical practice in the coming years, enhancing PD management.