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Updated: Aug 16, 2026

Real-time Live Imaging of T-cell Signaling Complex Formation
Published on: June 23, 2013
Intracellular surveillance: controlling the assembly of MHC class I-peptide complexes
1Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA. peter.cresswell@yale.edu
Abstract:
MHC class I molecules bind with high affinity to peptides in the endoplasmic reticulum and display them on the cell surface. Here they are screened by CD8-positive T-lymphocytes for the presence of foreign, pathogen-derived peptides within the mass of self-peptides expressed. MHC class I assembly is a complicated process involving a number of accessory molecules, including specialized components as well as common chaperones. Our understanding of the mechanisms involved, while quite advanced, is far from complete.
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