Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.5K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

2.1K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K
Antigen Presenting Cells01:22

Antigen Presenting Cells

3.7K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.7K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.5K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.5K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.2K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A public HLA antigen associated with HLA-A9, Aw32, and Bw4.

Immunogenetics·2012
Same author

Impacts of participating in confidential enquiry panels: a qualitative study.

BJOG : an international journal of obstetrics and gynaecology·2006
Same author

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Defective antigen processing in GILT-free mice.

Science (New York, N.Y.)·2001
Same author

Multiple species express thiol oxidoreductases related to GILT.

Immunogenetics·2001
Same author

Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).

Proceedings of the National Academy of Sciences of the United States of America·2001
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

12.4K

Antigen recognition by T lymphocytes.

P Cresswell1

  • 1Peter Cresswell is at the Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710, USA.

Immunology Today
|October 8, 2014
PubMed
Summary
This summary is machine-generated.

Investigating T cell antigen recognition, this study explores whether antigen processing is essential for helper T cells. It examines how processing impacts antigen association with MHC class II molecules and T cell receptors within antigen-presenting cells.

More Related Videos

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.7K
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

12.4K

Related Experiment Videos

Last Updated: Apr 22, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

12.4K
Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.7K
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

12.4K

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • T cell recognition of antigens is crucial for adaptive immunity.
  • The precise mechanisms of antigen processing and presentation remain incompletely understood.
  • Key questions surround the necessity of antigen processing for helper T cell activation.

Purpose of the Study:

  • To address fundamental questions regarding T cell antigen recognition mechanisms.
  • To investigate the role of antigen processing in helper T cell recognition.
  • To elucidate the interaction between processed antigens, MHC class II molecules, and T cell receptors.

Main Methods:

  • Discussion and synthesis of existing research and meeting presentations.
  • Theoretical analysis of antigen processing pathways.
  • Examination of molecular interactions in antigen presentation.

Main Results:

  • Antigen processing is a critical step for T cell recognition, particularly for helper T cells.
  • Processing influences the specific antigenic epitopes that bind to MHC class II molecules (la antigens).
  • The site of antigen processing and its association with MHC class II molecules within antigen-presenting cells (APCs) are key areas of investigation.

Conclusions:

  • Further research is needed to fully delineate the intricacies of antigen processing and T cell receptor engagement.
  • Understanding these mechanisms is vital for developing effective immunotherapies and vaccines.
  • The interplay between antigen processing, MHC class II association, and T cell recognition requires continued study.