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[The developing risks of the allergic child]

A Sabbah1

  • 1Laboratoire d'Immuno-Allergologie-CHU-F-49033 Angers.

Allergie Et Immunologie
|February 24, 2001
PubMed

Insights

Egg allergy in infants can predict future respiratory issues like asthma. Early detection using specific allergy tests can help manage and potentially prevent the progression of allergic diseases in children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Clinical Immunology
  • Environmental Allergens

Context:

  • Infant egg allergy affects 6% of infants, with a significant portion progressing to other allergic conditions.
  • A substantial percentage of infants with egg allergy are at risk for developing sensitivity to airborne allergens (pneumoallergens).
  • There is a 50% progression rate to asthma among infants with egg allergy who become sensitive to pneumoallergens.

Purpose:

  • To identify early indicators of allergic disease progression in infants.
  • To evaluate the utility of specific in vitro allergy tests for risk assessment.
  • To outline diagnostic methods for identifying specific food and aeroallergens.

Summary:

  • Precise clinical evaluation and targeted in vitro testing (F x 5 for foods, Phadiatop for pneumoallergens) can identify infants at risk.
  • Specific allergens can be further identified using skin tests or specific IgE measurements (CAP-RAST by UNICAP).
  • This approach aims to mitigate the 'allergic march' or course of allergic disease in children.

Impact:

  • Enables early intervention strategies for infants with allergic predispositions.
  • Facilitates personalized allergy management plans based on specific allergen identification.
  • Potentially reduces the incidence and severity of asthma and other allergic conditions in at-risk children.

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