Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Physiopathologic implications of telomerase].

A Santos Ruiz, M Cascales Angosto

    Anales De La Real Academia Nacional De Medicina
    |February 24, 2001
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Severo Ochoa de Albornoz].

    Anales de la Real Academia Nacional de Medicina·1994
    Same author

    [Changes in lipid metabolism which accompany thioacetamide-induced cirrhosis].

    Revista espanola de oncologia·1982
    Same author

    Effect of periodate oxidation on the properties of dopamine-beta-hydroxylase.

    Biochimie·1977
    Same author

    [Kinetic properties of membrane dopamine-beta-hydroxylase. ].

    FEBS letters·1976
    Same author

    [Changes of zinc metabolism in liver cirrhosis with and without encephalopathy].

    Revista clinica espanola·1968
    Same author

    [Metabolic studies with Zn65. VII. Biological half-life of zinc in the guinea pig].

    Revista espanola de fisiologia·1965
    Same journal

    [Not Available].

    Anales de la Real Academia Nacional de Medicina·2016
    Same journal

    [Not Available].

    Anales de la Real Academia Nacional de Medicina·2016
    Same journal

    [MEDICINE: THE MAIN ENGINE OF THE GENERATION OF 1914].

    Anales de la Real Academia Nacional de Medicina·2016
    Same journal

    [Not Available].

    Anales de la Real Academia Nacional de Medicina·2016
    Same journal

    [JULIAN CALLEJA AND CARLOS MARÍA CORTEZO. TWO KEY FIGURES IN THE CENTENNIAL BUILDING THE ROYAL ACADEMY OF MEDICINE].

    Anales de la Real Academia Nacional de Medicina·2016
    Same journal

    [Not Available].

    Anales de la Real Academia Nacional de Medicina·2016
    See all related articles

    Telomerase, an enzyme extending telomeres, is active in stem and cancer cells but repressed in normal somatic cells. Its activation can lead to cell immortalization and cancer, impacting aging and therapy.

    Area of Science:

    • Molecular Biology
    • Cell Biology
    • Genetics

    Background:

    • Telomerase is an enzyme crucial for maintaining telomere length in eukaryotic chromosomes.
    • Its activity is typically high in germ cells, stem cells, and cancer cells, but low in normal somatic cells.
    • Telomere shortening acts as a cellular clock, regulating cell division and senescence.

    Discussion:

    • Forced expression of telomerase in senescent cells can lead to immortalization and potentially malignant transformation.
    • Dysregulation of telomerase activity is implicated in the aging process and the development of cancer.
    • Understanding telomerase regulation is vital for developing targeted therapies for age-related diseases and cancer.

    Key Insights:

    • Telomerase activity is a key determinant of cellular lifespan and neoplastic progression.

    Related Experiment Videos

  • The balance of telomerase expression and telomere length is critical for cellular homeostasis.
  • Multifactorial regulation of telomerase involves gene expression, protein interactions, and phosphorylation.

    • Outlook:

    • Further research into telomerase regulation may unlock novel therapeutic strategies for cancer and aging.
    • Targeting telomerase offers a promising avenue for anti-cancer drug development.
    • Investigating telomerase modulation could provide insights into regenerative medicine and longevity research.